Kalendář akcí VŠCHT Praha
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20.9.2019 (pá)

14:00 - 16:00Expeditious Synthesis of Bacterial Glycoconjugates     

Bacterial glycoconjugates are comprised of rare D- and L- deoxy amino sugars, which are not present on the human cell surface. This peculiar structural difference allows discrimination between the pathogen and the host cell and offers avenues for target-specific drug discovery and carbohydrate-based vaccine development. However, they cannot be isolated with sufficient purity in acceptable amounts, and therefore chemical synthesis is a crucial step toward the development of these products.1 We recently established short and convenient methodologies for the synthesis of orthogonally protected bacterial D and L-deoxy amino hexopyranoside and glycosamine building blocks starting from cheaply available D-mannose and L-rhamnose.2–4 The one-pot protocols rely on highly regioselective nucleophilic displacements of triflates. These procedures have been applied to the synthesis of various bacterial glycoconjugates2–9 as well as metabolic oligosaccharide…




14:00 - 15:00Zasedání akademického senátu FCHI     

Zveme vás na 40. řádné zasedání Akademického senátu FCHI, které se bude konat 7.8. v 11:00 na sekretariátu ÚFCH - místnost A135.




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